BioDiscovery Blog

Gene Ontology Enrichment: Which Pathways or Processes are enriched in my data set?

Gain a better understanding of the specific pathways and processes that may be targeted by copy number alteration for whole genome and specific regions.

Identifying Statistically Significant Frequent Copy Number Alterations: STAC and GISTIC

Find out what the most frequent alterations are when dealing with large data sets and if they statistically significant copy number alterations.

GC Wave Correction – when to use it, how and why

It is common to have questions about when and whether to use GC wave correction and what causes waviness. This article can help clarify your questions.

How to obtain the number of tests performed for multiple testing when using the Comparisons tool in Nexus Copy Number

Learn this little trick to obtaining the number of tests performed for FDR correction when using the comparisons tool in Nexus Copy Number.

Diploid Recentering: When, Why and How

Since cancer frequently undergoes copy number changes it is important to run a quick check to validate if the the “normal” areas normal. Learn more!

Welcome to the new!

Introducing our new and improved website and blog! We hope you love the new layout of our site, and find it easier to navigate through all of our information and resources.

A review of “Emerging landscape of oncogenic signatures across human cancer”

This review provides an alternate approach to indentifying driver alterations, by classifying individual tumors based on their functional events.

Using CoNIFER to Detect Copy Number Variations from Exome Sequencing Data

CoNIFER can be used to discover CNVs that might be missed by standard practices. Look at our considerations when evaluating the CoNIFER algorithm.

Estimating Copy Number From Log Ratios

Take a look at some common questions that customers have about using Nexus, and receive some advice on calculating the actual copy number of samples in Nexus.

From Raw Data to Copy Number Calls – Data processing workflow in Nexus Copy Number

Take a look at how Nexus Copy Number handles the different “Raw Data” and the three steps to analyzing the data.